Furthermore, exphy reversed the ethanolinduced increase in lipid peroxidation. Thirty two adult male rats were used in this study four groups and several parameters were determined to assess any degree of protection. Evaluation of gastroprotective activity of myristica fragrans on. Wistar rats were pretreated with omeprazole 20mgkg body weight, 50mgkg, 100mgkg and 150mgkg per body weight of methanol and water extract separately. For this reason, many natural compounds have been explored as alternatives for these drugs. During ethanol induced gastric oxidative stress, the accumulation of oxygenderived free radicals in ulcer areas could surpass the oxidation resistance of antioxidant defense system hence start intrinsic pathway of apoptosis and activate bax, a proapoptotic member of bcl2 family proteins.
Diosmin protects against ethanolinduced gastric injury in. To evaluate the antiulcer activity of caesalpinia pulcherrima on ethanol induced gastric lesion in albino rat. Ethanolinduced gastric ulcer in rats and intervention of. Protective effects of quercetin in ethanol induced gastric ulcer 41 lipoproteins, and other lipidcontaining structures under conditions of oxidative stress. Administration of ethanol causes gastric necrotic damage and subsequent inflammatory cell infiltration and reduces the secretion of bicarbonate, gastric mucus, and nitric oxide. This study aimed to evaluate acute toxicity and ulcer inhibitory effect of 2pentadecanone as a ketone bioactive compound against ethanolinduced gastric ulcer in sprague dawley rats. Ethanolinduced gastric ulceration in rats semantic scholar. The ulcer areas seen in the rats treated with znlscn were significantly lower p pdf is available to subscribers only. Antiulcer activity of swietenia mahagoni leaf extract in ethanolinduced gastric mucosal damage in rats. Ahvaz jundishapur university of medical sciences guidelines for. The chemical composition of plant extract, the unsaponi. Antiulcer and antioxidant activity of moringa oleifera.
The antiulcer activity of ethanolic extract of flowers of c aesalpinia pulcherrima cpfe was compared with standard drug famotidine. The histological study supported the observed gastroprotective activity of exphy, showing a reduced inflammatory response. The gastroprotective effect of ga could be partly related to the stimulations of. The experimental mice were randomly divided into control, model, omeprazole 20 mgkg, orally and ara 10, 20 and 40 mgkg, orally. Antiulcerogenic effect of cuphea ignea extract against. The gastro protective effects of cibotium barometz hair on.
Ethanolinduced gastric injury is a key experimental model commonly utilized for preclinical assessment of agents with potential antiulcer activity since ethanol has been regarded as a leading cause of gastric ulcer in humans 9, 10, 12. After the treatment period, rats received oral administration of 1. Based on these results, a model for the pathogenesis of ethanolinduced gastric lesions is proposed. Prevention of hclethanol induced gastric mucosal injury. Evidencebased complementary and alternative medicine. The present study showed that zingerone has a protective effect on the ethanolinduced gastric ulcer, which may be due to its free radical scavenging activity. Antioxidant activity of ethanol extract of rhizome. Protective effect of falcaria vulgaris extract on ethanol.
Relationship between ethanolinduced gastritis and gastric ulcer. Therefore, the present study was performed to evaluate the gastropreventive effect of aqueous ethanolic extract of c. For the first time, this study demonstrates that administration of zingerone at the doses of 100 and 200 mgkg decreases the lipid peroxidation in the stomach and attenuates the ethanolinduced gastric ulcer in the rat. The present work was done to investigate the possible effects of nigella sativa oil nso on gastric secretion and ethanolinduced ulcer in rats. Gastric ulcer appeared as elongated bands of hemorrhagic lesions in which the elongated lesions are the pathological features that related with ethanol induced ulcer. We performed histological as well as immunohistochemical examinations to explore the therapeutic. Ethanolinduced gastric ulcer is a common animal model to investigate the new antiulcer drugs. Omeprazole is a proton pump inhibitor drug that has being employed for the. Studies on the mechanism of ethanolinduced gastric damage. Gastric ulcer gu is the most common health concern that occurs due to alcohol consumption, smoking and physiological stress.
The ulcer index and curative ratio were calculated for all the groups. Limonia acidissima exhibited antiulcer activity against ethanol induced ulcer in rats. Gastric ulcer index, microscopic score, elevated dna fragmentation and chemiluminescence levels of the saline. The length mm and the width mm of each band was measured using planimeter 10 mm. Issn 24721646 of punicalagin against ethanolinduced. Pdf gastroprotective effects of betanin against ethanol. Research article ethanolinduced gastric ulcer in male.
Gastroprotective effect of zingerone on ethanolinduced gastric. Therapeutic effect of low molecular weight chitosan. Ethanolinduced acute gastric ulceration eigu is widely studied. Biochanin a gastroprotective effects in ethanolinduced. Oral administration of ethanol extract of the rhizome ofpirorhiza kurroa at a dose of 20mgkg body weight, for 10 consecutive days, was found to enhance the rate of healing on indomethacininduced gastric ulcer in rats, compared to the ulcerated group. Gastroprotective activity of myristica fragrans was investigated by determination of gastric ph, free acidity, ulcer index score and on histopathological basis. Gastric lesions were induced in rats by oral administration of ethanol 80% ethanol 1 ml, p. Gastroprotective effect of araloside a on ethanol and. Seven groups of sprague dawley sd rats were administered 10% tween 20 in the normal control and ulcer control groups, and. A zinc morpholine complex prevents hclethanolinduced. Protective effect of areca catechu leaf ethanol extract. Gastric ulcer in mice was induced by intragastric administration. The aim of this study was assessment the antiulcer effects of c. To evaluate the role of ala treatment on the healing of acetic acidinduced gastric ulcer, rats were given ala 35 mgkgday or saline for 3 days before the induction of ulcer and the treatment was continued twice daily for 2 days early or 10 days late until they were decapitated.
Oecd 2002 organization for economic cooperation and development guideline no. In this study, we have investigated the effectiveness of areca catechu leaf ethanol extract ace for treating ethanolinduced gastric ulcers in mice. Hydroxyproline, a serum biomarker candidate for gastric. Pdf ulceroprotective effect of methanol extract of. The animals were sacrificed after 4 hr and functional indices of ulcer activity was studied in all rats and compared with that of nonulcer induced ones. Therefore, the fact that quercetin decreased lipid peroxidation might mean that quercetin has an antioxidant effect.
Effects of nigella sativa oil on gastric secretion and. A comparison study of metabolic analysis of gastric ulcer models induced by ethanol, stress, and aspirin kenichiro takeuchi1, maki ohishi2, keiko endo2, kenichi suzumura3, hitoshi naraoka1, takeji ohata1, jiro seki1, yoichi miyamae1, masashi honma4 and tomoyoshi soga2. The aim of this study was to elucidate the gastroprotective activity and possible mechanism of involvement of araloside a ara against ethanol and aspirininduced gastric ulcer in mice. Mechanisms of gastroprotective effects of ethanolic leaf extract of. Santha maria1, surya devarakonda 1, ajay kumar tv 2 and n. Gallic acid ga showed protective effects against ethanolinduced gastric ulcer in rats. All the treatment doses of the extracts aepo and mepo and ranitidine suppressed the ulceration induced by ethanol. These results were further supported by histopathological findings which revealed the curing effect of c. Ethanolinduced gastric ulcer an overview sciencedirect topics.
The gastroprotective effects of aqueous extract of h. The present study investigates the antiulcer activity of methanol extract of p. Seven groups of rats were orally pretreated with carboxymethylcellulose cmc as normal. Pdf gastroprotective effects of pistacia atlantica extract on. Pdf amelioration of ethanolinduced gastric ulcers in.
Some species of this family have been used traditionally in south and central americas folk medicine for treating stomach disorders. The possible involvements of lipid peroxidation, superoxide dismutase, and catalase were also investigated. Gastroprotective effect of gallic acid against ethanol. Stomach ulcers were induced by oral ingestion of hydrochloride hcl ethanol or indomethacin.
Moreover, the alcoholinduced decrease in stomach antioxidant enzyme activity found in the ulcer control group was prevented by exphy pretreatment. Ethanolinduced hyperemia was markedly reduced by lipoxygenaseselective inhibitors bw755c or nordihydroguaiaretic acid, or by the h 1antihistamine pyrilamine, but not by indomethacin, cimetidine, phentolamine, or methysergide. Ketones have been reported to possess antiinflammatory, antioxidant and antiulcer activities. Ulceration was induced by oral administration of absolute ethanol 1cm3kg body weight. Alphalipoic acid improves acetic acidinduced gastric. Hericium erinaceus is a famous tonic in oriental medicine. The effect of znlscn on the ulcer area induced by hclethanol is shown in fig. Cuphea ignea is one of the herbal resources belonging to lythraceae family. Research paper ulcer prevention effect of 3,4,5tihydroxy. Balakrishnan1 school of biomedicine 1, asia metropolitan university, g8, jalan kemacahaya 11, batu 9, 43200 cheras, selangor, malaysia. Accordingly, this study was designed to examine gastroprotective action of pcg against ethanol induced gastric ulcer.
Gastroprotective effect of zingerone on ethanolinduced. Seven groups of sprague dawley sd rats were administered 10% tween 20 in the normal control and ulcer control groups, and omeprazole 20 mgkg and 62. Evaluation of gastroprotective activity of myristica. Phytochemical studies and antiulcer activity of limonia. All animals were used according to the guidelines of the committee on care and use.
In this experiment, a novel biocompatible material, low molecular weight chitosan containing sepia ink lmcs was prepared for treating ethanolinduced gastric ulcer, which mainly based on two considerations. Protective effect of chelerythrine against ethanolinduced. Methods omeprazole omeprazole, as an antiulcer medicine and positive control was purchased from the university of malaya, medical center. Effects of zinc sulfate on ethanol and indomethacininduced ulceration and. Gastric ulcer was induced in overnight fasted rats that. The experimental protocol and ethanolinduced gastric lesions method. Antiulcerogenic activity of scutia buxifolia on gastric ulcers induced. Gastric ulcers were induced by ethanol 96%, 5 mlkg, po in male wistar rats and zingerone 50, 100, and 200 mgkg was administrated orally. Ulcer can be induced by administration of hpylori, nonsteroidal antiinflammatory drugs.